Reference Papers

Functional properties of wasabi and horseradish. K. Kinae, N Masuda, H. Shin, I.S. Furugori, M. Shimoi. Biofactors. 2000; 13(1-4): 265-9 0951-6433.

6-Methylsulfinylhexyl isothiocyanate and its homologues as food-orginated compounds with antibacterial activities against Escherichia coli and Staphylococcus aureus. M. Ono, H. Tesaki, S. Tanabe, S. Watanabe. Biosci-Siotechnol-Biochem. 1998 Feb; 62(2): 363-5 0916-8451.

The effect of 6-Methylsulfinylhexyl isothiocyanate isolated from Wasabia Japonica (wasabi) on 4-(methylinitrosamino)-1-(3-pyridyl)-1-buatnone-induced lung tumorigenesis in mice. T. Yano, T. Yajima, S. Virgona, N. Yano, Y. Otani, S.Kumagai, H. Sakurai, H. Kishimoto, M. Ichikawa. Caner-Lett. 2000 Jul 31; 155(2): 115-20 0304-3835.

Suppressive effect of wasabi (pungent Japanese spice) on gastric carcinogenesis induced by MNNG in rats. T. Tanida, N. Kawaura, A. Takahashi, A. Sawada, K. Shimoyama. Nutr-Cancer. 1991; 16(1): 53-8 0163-5581.

Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, wasabi. T.Morimitsu, Y. Hayashi, K. Nakagawa, Y. Horio, F. Uchida, K. Osawa. Biofactors. 2000; 13(1-4): 271-6 0951-6433.

A sulforaphone analogue that potently activates the Nrf2-dependent detoxification pathway. Koji Morimitsu, Yasujiro Nakagawa, Yoko Hayashi, Kazuhiro Fujii, Hiroyuki Kumagai, Takeshi Nakamura, Yoshimasa Osawa, Toshihiko Horio, Fumihiko Itoh, Ken Iida, Katsuyuki Yamamoto, Masayuki Uchida. J-Biol-Chem. 2002 Feb 1; 277(5): 3456-63 0021-9258.

Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model. Sylvie Krul, Cyrille Humblot, Christele Philippe, Catherine Vermeulen, Martijn van Nuenen, Marleen Havenaar, Robert Rabot. Carcinogenesis. 2002 Jun; 23(6): 1009-16 0143-3334.

Effect of naturally occurring organosulfur compounds on nitric oxide production in lipopolysaccharide-activated macrophages. Hisao Ippoushi, Katsunari Itou, Hidekazu Azuma, Keiko Higashio. Life-Sci. 2002 Jun 14; 71(4): 411-9 0024-3205.

Dietary compounds that induce cancer preventative phase 2 enzymes activate apoptosis at comparable doses in HT29 colon carcinoma cells. D.P. Kirlin, W.G. Cai, J. DeLong, M.J. Patten, E.J. Jones. J-Nutr. 1999 Oct; 129(10): 1827-35 0022-3166.

Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetables. P. Shapiro, T. A. Fahey, J.M. Wade, M.L. Stephenson, K.K. Talslay.Cancer-Epidemiol-Biomarkers-Prev. 1998 Dec; 7(12): 1091-100 1055-9965.

Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. F.J. Xu, K. Thornalley. Biochem-Pharmacol. 2000 Jul15; 60(2): 221-31 0006-2952.

Antibacterial mechanism of allyl isothiocyanate. C.I. Lin, C.M. Preston. J.F. Wei. J-Food-Prot. 2000 Jun; 63(6): 727-34 0362-028X.

Formation of allyl isothiocyanate from sinigrin in the digestive tract of rats monoassociated with a human colonic strain of Bacteroides thetaiotaomicron. A. Elfoul, L. Rabot, S. Khelifa, N. Quinsac, A. Duguay, A. Rimbault. FEMS-Microbiol-Lett. 2001 Apr 1; 197(1): 99-103 0378-1097.

Selective toxicity of compounds naturally present in food toward the transformed phenotype of human colorectal cell line HT29. I.T. Musk, S.R. Stephenson, P. Smith, T.K. Stening, P. Fyfe, D. Johnson. Nutr-Cancer. 1995; 24(3): 289-98 0163-5581.

Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29. I.T. Musk, S.R. Johnson. Carcinogenesis. 1993 Oct; 14(10): 2079-83 0143-3334.

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